منابع مشابه
uPARAP Function in Cutaneous Wound Repair
Optimal skin wound healing relies on tight balance between collagen synthesis and degradation in new tissue formation and remodeling phases. The endocytic receptor uPARAP regulates collagen uptake and intracellular degradation. In this study we examined cutaneous wound repair response of uPARAP null (uPARAP-/-) mice. Full thickness wounds were created on dorsal surface of uPARAP-/- or their wil...
متن کاملMast Cells in Cutaneous Wound Healing
Mast cells are suggested to participate in wound healing, but their specific role has remained obscure. Mast cells are a rich source of inflammatory mediators, such as histamine, proteoglycans, the proteases tryptase and chymase, lipids, growth factors and cytokines. Among these mediators, there are many that have effects on cell growth, tissue turnover and repair. The aim of this study was to ...
متن کاملThe commonality of cutaneous wound repair and lung injury.
Richard A. Clark, M.D. Soluble mediators, formed blood elements, extracellular matrix (ECM) proteins, and parenchymal cells integrate in dynamic interactive processes to effect normal repair of injured tissue. Unencumbered, these processes follow a specific time sequence. These wound repair events can be temporally grouped into inflammation, tissue formation, and tissue remodeling; however, the...
متن کاملPeriostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair.
The matricellular protein periostin is expressed in the skin. Although periostin has been hypothesized to contribute to dermal homeostasis and repair, this has not been directly tested. To assess the contribution of periostin to dermal healing, 6 mm full-thickness excisional wounds were created in the skin of periostin-knockout and wild-type, sex-matched control mice. In wild-type mice, periost...
متن کاملThe wound repair response controls outcome to cutaneous leishmaniasis.
Chronic microbial infections are associated with fibrotic and inflammatory reactions known as granulomas showing similarities to wound-healing and tissue repair processes. We have previously mapped three leishmaniasis susceptibility loci, designated lmr1, -2, and -3, which exert their effect independently of T cell immune responses. Here, we show that the wound repair response is critically imp...
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ژورنال
عنوان ژورنال: Microbiology Spectrum
سال: 2016
ISSN: 2165-0497
DOI: 10.1128/microbiolspec.mchd-0017-2015